Clinical Correlates of the NR3C1 Gene Methylation at Various Stages of Psychosis.

ABSTRACT:

Background

Dysregulation of epigenetic processes might account for alterations of the hypothalamic-pituitary-adrenal axis observed in patients with schizophrenia. Therefore, in this study, we aimed to investigate methylation of the glucocorticoid receptor (NR3C1) gene in patients with schizophrenia-spectrum disorders, individuals at familial high risk of schizophrenia (FHR-P), and healthy controls with respect to clinical manifestation and a history of psychosocial stressors.

Methods

We recruited 40 first-episode psychosis patients, 45 acutely relapsed schizophrenia (SCZ-AR) patients, 39 FHR-P individuals, and 56 healthy controls. The level of methylation at 9 CpG sites of the NR3C1 gene was determined using pyrosequencing.

Results

The level of NR3C1 methylation was s

SUBMITTER: Misiak B 

PROVIDER: S-EPMC8059494 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature