Microbial community composition interacts with local abiotic conditions to drive colonization resistance in human gut microbiome samples.

ABSTRACT: Biological invasions can alter ecosystem stability and function, and predicting what happens when a new species or strain arrives remains a major challenge in ecology. In the mammalian gastrointestinal tract, susceptibility of the resident microbial community to invasion by pathogens has important implications for host health. However, at the community level, it is unclear whether susceptibility to invasion depends mostly on resident community composition (which microbes are present), or also on local abiotic conditions (such as nutrient status). Here, we used a gut microcosm system to disentangle some of the drivers of susceptibility to invasion in microbial communities sampled from humans. We found resident microbial communities inhibited an invading Escherichia coli strain, compa

SUBMITTER: Baumgartner M 

PROVIDER: S-EPMC8059542 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature