Comprehensive investigation of sources of misclassification errors in routine HIV testing in Zimbabwe.

ABSTRACT:

Introduction

Misclassification errors have been reported in rapid diagnostic HIV tests (RDTs) in sub-Saharan African countries. These errors can lead to missed opportunities for prevention-of-mother-to-child-transmission (PMTCT), early infant diagnosis and adult HIV-prevention, unnecessary lifelong antiretroviral treatment (ART) and wasted resources. Few national estimates or systematic quantifications of sources of errors have been produced. We conducted a comprehensive assessment of possible sources of misclassification errors in routine HIV testing in Zimbabwe.

Methods

RDT-based HIV test results were extracted from routine PMTCT programme records at 62 sites during national antenatal HIV surveillance in 2017. Positive- (PPA) and negative-percent agreement (NPA) for HIV RD

SUBMITTER: Gregson S 

PROVIDER: S-EPMC8059712 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature