A comprehensive evaluation of skin aging-related circular RNA expression profiles.

ABSTRACT:

Background

Circular RNAs (circRNAs) have been shown to play important regulatory roles in a range of both pathological and physiological contexts, but their functions in the context of skin aging remain to be clarified. In the present study, we therefore, profiled circRNA expression profiles in four pairs of aged and non-aged skin samples to identify identifying differentially expressed circRNAs that may offer clinical value as biomarkers of the skin aging process.

Methods

We utilized an RNA-seq to profile the levels of circRNAs in eyelid tissue samples, with qRT-PCR being used to confirm these RNA-seq results, and with bioinformatics approaches being used to predict downstream target miRNAs for differentially expressed circRNAs.

Results

In total, we identified 571 ci

SUBMITTER: Wang L 

PROVIDER: S-EPMC8059755 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature