Patterns of metformin monotherapy discontinuation and reinitiation in people with type 2 diabetes mellitus in New Zealand.

ABSTRACT:

Aim

To describe the patterns of discontinuation and reinitiation in new users of metformin monotherapy in New Zealand, overall and according to person- and healthcare-related factors.

Materials and methods

We created a cohort (n = 85,066) of all patients in New Zealand with type 2 diabetes mellitus who initiated metformin monotherapy between 1 January 2006 and 30 September 2014 from the national data collections, and followed them until the earlier of their death or 31 December 2015. Discontinuation was defined as a gap in possession of metformin monotherapy of ≥90 days. We explored patterns of discontinuation and reinitiation using competing risks methods.

Results

After 1 year of follow-up, 28% of cohort members had discontinued metformin monotherapy at least once; t

SUBMITTER: Horsburgh S 

PROVIDER: S-EPMC8059805 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature