Gut microbiota in Immunoglobulin A Nephropathy: a Malaysian Perspective.

ABSTRACT:

Introduction

The alteration of the gut microbiome in the gut-kidney axis has been associated with a pro-inflammatory state and chronic kidney disease (CKD). A small-scaled Italian study has shown an association between the gut microbiome and Immunoglobulin A Nephropathy (IgAN). However, there is no data on gut microbiota in IgAN in the Asian population. This study compares the gut microbial abundance and diversity between healthy volunteers and Malaysian IgAN cohort.

Methods

A comparative cross-sectional study was conducted involving biopsy-proven IgAN patients in clinical remission with matched controls in a Malaysian tertiary centre. Demographic data, routine blood and urine results were recorded. Stool samples were collected and their DNA was extracted by 16S rRNA gene se

SUBMITTER: Sugurmar ANK 

PROVIDER: S-EPMC8060124 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature