Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice.

ABSTRACT: Resistance exercise exerts beneficial effects on glycemic control, which could be mediated by exercise-induced humoral factors released in the bloodstream. Here, we used C57Bl/6 healthy mice, submitted to resistance exercise training for 10 weeks. Trained mice presented higher muscle weight and maximum voluntary carrying capacity, combined with reduced body weight gain and fat deposition. Resistance training improved glucose tolerance and reduced glycemia, with no alterations in insulin sensitivity. In addition, trained mice displayed higher insulinemia in fed state, associated with increased glucose-stimulated insulin secretion. Islets from trained mice showed reduced expression of genes related to endoplasmic reticulum (ER) stress, associated with increased expression of Ins2. INS-1E bet

SUBMITTER: Bronczek GA 

PROVIDER: S-EPMC8060292 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature