Ontology highlight
ABSTRACT:
SUBMITTER: Fries SJ
PROVIDER: S-EPMC8060413 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Fries Sandra J SJ Braun Theresa S TS Globisch Christoph C Peter Christine C Drescher Malte M Deuerling Elke E
Scientific reports 20210421 1
The eukaryotic ribosome-associated complex (RAC) plays a significant role in de novo protein folding. Its unique interaction with the ribosome, comprising contacts to both ribosomal subunits, suggests a RAC-mediated coordination between translation elongation and co-translational protein folding. Here, we apply electron paramagnetic resonance (EPR) spectroscopy combined with site-directed spin labeling (SDSL) to gain deeper insights into a RAC-ribosome contact affecting translational accuracy. W ...[more]