Vascular Aging in the Invertebrate Chordate, Botryllus schlosseri.

ABSTRACT: Vascular diseases affect over 1 billion people worldwide and are highly prevalent among the elderly, due to a progressive deterioration of the structure of vascular cells. Most of our understanding of these age-related cellular changes comes from in vitro studies on human cell lines. Further studies of the mechanisms underlying vascular aging in vivo are needed to provide insight into the pathobiology of age-associated vascular diseases, but are difficult to carry out on vertebrate model organisms. We are studying the effects of aging on the vasculature of the invertebrate chordate, Botryllus schlosseri. This extracorporeal vascular network of Botryllus is transparent and particularly amenable to imaging and manipulation. Here we use a combination of transcripto

SUBMITTER: Rodriguez D 

PROVIDER: S-EPMC8060491 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature