Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development.

ABSTRACT: Disruption of FOXF2, encoding a member of the Forkhead family transcription factors, has been associated with cleft palate in humans and mice. FOXF2 is located in a conserved gene cluster containing FOXQ1, FOXF2, and FOXC1. We found that expression of Foxq1 is dramatically upregulated in the embryonic palatal mesenchyme in Foxf2 ^-/- mouse embryos. We show here that the Foxf2 promoter-deletion mutation caused dramatically increased expression of the cis-linked Foxq1 allele but had little effect on the Foxq1 allele in trans. We analyzed effects of the Foxf2 mutation on the expression of other neighboring genes and compared those effects with the chromatin domain structure and recently identi

SUBMITTER: Xu J 

PROVIDER: S-EPMC8060495 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature