Does antiretroviral therapy cause congenital malformations? A systematic review and meta-analysis.

ABSTRACT:

Objectives

This meta-analysis investigated the risk of congenital anomalies among infants of human immunodeficiency virus-infected pregnant women who were exposed to antiretroviral therapy (ART).

Methods

Cohort studies, case-control studies, randomized controlled trials, and controlled clinical trials were reviewed by searching MEDLINE/PubMed, Embase, Web of Science, Scopus, AIDSLINE, CINAHL, Cochrane Library, and Google/Google Scholar. Methodological quality was assessed using the GRADE evaluation. A DerSimonian and Laird random-effects model was used. Subgroup analyses and meta-regression were used to investigate heterogeneity.

Results

The electronic searches yielded 765 items. After quality assessment and grading, 30 studies were suitable for metaanalysis. In total

SUBMITTER: Alemu FM 

PROVIDER: S-EPMC8060528 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature