Ultra-high field (7T) functional magnetic resonance imaging in amyotrophic lateral sclerosis: a pilot study.

ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the central nervous system that results in a progressive loss of motor function and ultimately death. It is critical, yet also challenging, to develop non-invasive biomarkers to identify, localize, measure and/or track biological mechanisms implicated in ALS. Such biomarkers may also provide clues to identify potential molecular targets for future therapeutic trials. Herein we report on a pilot study involving twelve participants with ALS and nine age-matched healthy controls who underwent high-resolution resting state functional magnetic resonance imaging at an ultra-high field of 7 Tesla. A group-level whole-brain analysis revealed a disruption in long-range functional connectivity between the superior sensorimotor cor

SUBMITTER: Barry RL 

PROVIDER: S-EPMC8060594 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature