Association of Multigenerational Family History of Depression With Lifetime Depressive and Other Psychiatric Disorders in Children: Results from the Adolescent Brain Cognitive Development (ABCD) Study.

ABSTRACT:

Importance

Three-generation family studies of depression have established added risk of psychopathology for offspring with 2 previous generations affected with depression compared with 1 or none. Because of their rigorous methodology, there are few of these studies, and existing studies are limited by sample sizes. Consequently, the 3-generation family risk paradigm established in family studies can be a critical neuropsychiatric tool if similar transmission patterns are reliably demonstrated with the family history method.

Objective

To examine the association of multigenerational family history of depression with lifetime depressive disorders and other psychopathology in children.

Design, setting, and participants

In this analysis of the Adolescent Brain Cognitive De

SUBMITTER: van Dijk MT 

PROVIDER: S-EPMC8060885 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature