Characterization of a haplotype-reference panel for genotyping by low-pass sequencing in Swiss Large White pigs.

ABSTRACT:

Background

The key-ancestor approach has been frequently applied to prioritize individuals for whole-genome sequencing based on their marginal genetic contribution to current populations. Using this approach, we selected 70 key ancestors from two lines of the Swiss Large White breed that have been selected divergently for fertility and fattening traits and sequenced their genomes with short paired-end reads.

Results

Using pedigree records, we estimated the effective population size of the dam and sire line to 72 and 44, respectively. In order to assess sequence variation in both lines, we sequenced the genomes of 70 boars at an average coverage of 16.69-fold. The boars explained 87.95 and 95.35% of the genetic diversity of the breeding populations of the dam and sire line, r

SUBMITTER: Noskova A 

PROVIDER: S-EPMC8061004 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature