Cigarette smoke-associated inflammation impairs bone remodeling through NFκB activation.

ABSTRACT:

Background

Cigarette smoking constitutes a major lifestyle risk factor for osteoporosis and hip fracture. It is reported to impair the outcome of many clinical procedures, such as wound infection treatment and fracture healing. Importantly, although several studies have already demonstrated the negative correlation between cigarette consume and impaired bone homeostasis, there is still a poor understanding of how does smoking affect bone health, due to the lack of an adequately designed animal model. Our goal was to determine that cigarette smoke exposure impairs the dynamic bone remodeling process through induction of bone resorption and inhibition of bone formation.

Methods

We developed cigarette smoke exposure protocols exposing mice to environmental smoking for 10 days o

SUBMITTER: Lu Y 

PROVIDER: S-EPMC8061040 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature