Human brain region-specific variably methylated regions are enriched for heritability of distinct neuropsychiatric traits.

ABSTRACT:

Background

DNA methylation dynamics in the brain are associated with normal development and neuropsychiatric disease and differ across functionally distinct brain regions. Previous studies of genome-wide methylation differences among human brain regions focus on limited numbers of individuals and one to two brain regions.

Results

Using GTEx samples, we generate a resource of DNA methylation in purified neuronal nuclei from 8 brain regions as well as lung and thyroid tissues from 12 to 23 donors. We identify differentially methylated regions between brain regions among neuronal nuclei in both CpG (181,146) and non-CpG (264,868) contexts, few of which were unique to a single pairwise comparison. This significantly expands the knowledge of differential methylation across the br

SUBMITTER: Rizzardi LF 

PROVIDER: S-EPMC8061076 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature