Resilience, plasticity and robustness in gene expression during aging in the brain of outbred deer mice.

ABSTRACT:

Background

Genes that belong to the same network are frequently co-expressed, but collectively, how the coordination of the whole transcriptome is perturbed during aging remains unclear. To explore this, we calculated the correlation of each gene in the transcriptome with every other, in the brain of young and older outbred deer mice (P. leucopus and P. maniculatus).

Results

In about 25 % of the genes, coordination was inversed during aging. Gene Ontology analysis in both species, for the genes that exhibited inverse transcriptomic coordination during aging pointed to alterations in the perception of smell, a known impairment occurring during aging. In P. leucopus, alterations in genes related to cholesterol metabolism were also identified. Among the genes that exhibited the

SUBMITTER: Soltanmohammadi E 

PROVIDER: S-EPMC8061204 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature