Epigenome-wide association study of level and change in cognitive abilities from midlife through late life.

ABSTRACT:

Background

Epigenetic mechanisms are important in aging and may be involved in late-life changes in cognitive abilities. We conducted an epigenome-wide association study of leukocyte DNA methylation in relation to level and change in cognitive abilities, from midlife through late life in 535 Swedish twins.

Results

Methylation levels were measured with the Infinium Human Methylation 450 K or Infinium MethylationEPIC array, and all sites passing quality control on both arrays were selected for analysis (n = 250,816). Empirical Bayes estimates of individual intercept (age 65), linear, and quadratic change were obtained from latent growth curve models of cognitive traits and used as outcomes in linear regression models. Significant sites (p < 2.4 × 10^-7) were followed

SUBMITTER: Karlsson IK 

PROVIDER: S-EPMC8061224 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature