Investigating Memory Updating in Mice Using the Objects in Updated Locations Task.

ABSTRACT: In the laboratory, memory is typically studied as a de novo experience, in which a naïve animal is exposed to a discrete learning event that is markedly different from its past experiences. Most real-world memories, however, are updates-modifications or additions-to existing memories. This is particularly true in the aging, experienced brain. To better understand memory updating, we have developed a new behavioral paradigm called the objects in updated locations (OUL) task. OUL relies on hippocampus-dependent spatial learning and has the advantage of being able to test both the original memory and the updated information in a single test session. Further, OUL relies on incidental learning that avoids unnecessary stress that might hinder the performance of aging animals. In OUL, animals fir

SUBMITTER: Wright DS 

PROVIDER: S-EPMC8061236 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature