Newborn metabolic vulnerability profile identifies preterm infants at risk for mortality and morbidity.

ABSTRACT:

Background

Identifying preterm infants at risk for mortality or major morbidity traditionally relies on gestational age, birth weight, and other clinical characteristics that offer underwhelming utility. We sought to determine whether a newborn metabolic vulnerability profile at birth can be used to evaluate risk for neonatal mortality and major morbidity in preterm infants.

Methods

This was a population-based retrospective cohort study of preterm infants born between 2005 and 2011 in California. We created a newborn metabolic vulnerability profile wherein maternal/infant characteristics along with routine newborn screening metabolites were evaluated for their association with neonatal mortality or major morbidity.

Results

Nine thousand six hundred and thirty-nine (9.

SUBMITTER: Oltman SP 

PROVIDER: S-EPMC8061535 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature