Rationales and uncertainties for aspirin use in COVID-19: a narrative review.

ABSTRACT:

Objectives

To review the pathophysiology of COVID-19 disease, potential aspirin targets on this pathogenesis and the potential role of aspirin in patients with COVID-19.

Design

Narrative review.

Setting

The online databases PubMed, OVID Medline and Cochrane Library were searched using relevant headlines from 1 January 2016 to 1 January 2021. International guidelines from relevant societies, journals and forums were also assessed for relevance.

Participants

Not applicable.

Results

A review of the selected literature revealed that clinical deterioration in COVID-19 is attributed to the interplay between endothelial dysfunction, coagulopathy and dysregulated inflammation. Aspirin has anti-inflammatory effects, antiplatelet aggregation, anticoagulant propert

SUBMITTER: Sayed Ahmed HA 

PROVIDER: S-EPMC8061559 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature