Circulating Plasma Metabolites and Cognitive Function in a Puerto Rican Cohort.

ABSTRACT:

Background

Minorities, including mainland Puerto Ricans, are impacted disproportionally by Alzheimer's disease (AD), dementia, and cognitive decline. Studying blood metabolomics in this population has the potential to probe the biological underpinnings of this health disparity.

Objective

We performed a comprehensive analysis of circulating plasma metabolites in relation to cognitive function in 736 participants from the Boston Puerto Rican Health Study (BPRHS) who underwent untargeted mass-spectrometry based metabolomics analysis and had undergone a battery of in-person cognitive testing at baseline.

Methods

After relevant exclusions, 621 metabolites were examined. We used multivariable regression, adjusted for age, sex, education, apolipoprotein E genotype, smoking,

SUBMITTER: Palacios N 

PROVIDER: S-EPMC8061579 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature