Ontology highlight
ABSTRACT:
SUBMITTER: Yu AM
PROVIDER: S-EPMC8061711 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Yu Angela M AM Gasper Paul M PM Cheng Luyi L Lai Lien B LB Kaur Simi S Gopalan Venkat V Chen Alan A AA Lucks Julius B JB
Molecular cell 20210115 4
The series of RNA folding events that occur during transcription can critically influence cellular RNA function. Here, we present reconstructing RNA dynamics from data (R2D2), a method to uncover details of cotranscriptional RNA folding. We model the folding of the Escherichia coli signal recognition particle (SRP) RNA and show that it requires specific local structural fluctuations within a key hairpin to engender efficient cotranscriptional conformational rearrangement into the functional stru ...[more]