Selfish chromosomal drive shapes recent centromeric histone evolution in monkeyflowers.

ABSTRACT: Centromeres are essential mediators of chromosomal segregation, but both centromeric DNA sequences and associated kinetochore proteins are paradoxically diverse across species. The selfish centromere model explains rapid evolution by both components via an arms-race scenario: centromeric DNA variants drive by distorting chromosomal transmission in female meiosis and attendant fitness costs select on interacting proteins to restore Mendelian inheritance. Although it is clear than centromeres can drive and that drive often carries costs, female meiotic drive has not been directly linked to selection on kinetochore proteins in any natural system. Here, we test the selfish model of centromere evolution in a yellow monkeyflower (Mimulus guttatus) population polymorphic for a costly driving cent

SUBMITTER: Finseth FR 

PROVIDER: S-EPMC8061799 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature