Gender differences in clinical presentation and illicit substance use during first episode psychosis: a natural language processing, electronic case register study.

ABSTRACT:

Objective

To determine whether gender differences in symptom presentation at first episode psychosis (FEP) remain even when controlling for substance use, age and ethnicity, using natural language processing applied to electronic health records (EHRs).

Design, setting and participants

Data were extracted from EHRs of 3350 people (62% male patients) who had presented to the South London and Maudsley NHS Trust with a FEP between 1 April 2007 and 31 March 2017. Logistic regression was used to examine gender differences in the presentation of positive, negative, depressive, mania and disorganisation symptoms.

Exposures for observational studies

Gender (male vs female).

Main outcomes and measures

Presence of positive, negative, depressive, mania and disorganisation

SUBMITTER: Irving J 

PROVIDER: S-EPMC8061860 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature