Suitability of IgG responses to multiple Plasmodium falciparum antigens as markers of transmission intensity and pattern.

ABSTRACT: Detection of antibody reactivity to appropriate, specific parasite antigens may constitute a sensitive and cost-effective alternative to current tools to monitor malaria transmission across different endemicity settings. This study aimed to determine the suitability of IgG responses to a number of P. falciparum antigens as markers of transmission intensity and pattern. Antibody responses to multiple malaria antigens were determined in 905 participants aged 1-12 years from three districts with low (Keta), medium (Hohoe) and high (Krachi) transmission intensity in the Volta region of Ghana. Blood film microscopy slides and dry blood spots (DBS) were obtained for parasitaemia detection and antibody measurement, respectively. Sera were eluted from DBS and levels of IgG specific for 10 malaria

SUBMITTER: Kyei-Baafour E 

PROVIDER: S-EPMC8062017 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature