Characterization and Analysis of the Skin Microbiota in Rosacea: A Case-Control Study.

ABSTRACT:

Background

The efficacy of antibiotics in rosacea treatment suggests a role for microorganisms in its pathophysiology. Growing concern over the adverse effects of antibiotic use presents a need for targeted antimicrobial treatment in rosacea.

Objective

We performed a case-control study to investigate the skin microbiota in patients with rosacea compared to controls matched by age, sex, and race.

Methods

Nineteen participants with rosacea, erythematotelangiectatic, papulopustular, or both, were matched to 19 rosacea-free controls. DNA was extracted from skin swabs of the nose and bilateral cheeks of participants. Sequencing of the V3V4 region of the bacterial 16S ribosomal RNA gene was performed using Illumina MiSeq and analyzed using QIIME/MetaStats 2.0 software.

R

SUBMITTER: Rainer BM 

PROVIDER: S-EPMC8062047 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature