Two-year outcomes after dextrose gel prophylaxis for neonatal hypoglycaemia.

ABSTRACT:

Objective

To determine the effect of prophylactic dextrose gel for prevention of neonatal hypoglycaemia on neurodevelopment and executive function at 2 years' corrected age.

Design

Prospective follow-up of a randomised trial.

Setting

New Zealand.

Patients

Participants from the pre-hypoglycaemia Prevention with Oral Dextrose (pre-hPOD) trial randomised to one of four dose regimes of buccal 40% dextrose gel or equivolume placebo.

Main outcome measures

Coprimary outcomes were neurosensory impairment and executive function. Secondary outcomes were components of the primary outcomes, neurology, anthropometry and health measures.

Results

We assessed 360 of 401 eligible children (90%) at 2 years' corrected age. There were no differences between dextrose

SUBMITTER: Griffith R 

PROVIDER: S-EPMC8062278 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature