Disrupted parahippocampal and midbrain function underlie slower verbal learning in adolescent-onset regular cannabis use.

ABSTRACT:

Rationale

Prolonged use of cannabis, the most widely used illicit drug worldwide, has been consistently associated with impairment in memory and verbal learning. Although the neurophysiological underpinnings of these impairments have been investigated previously using functional magnetic resonance imaging (fMRI), while performing memory tasks, the results of these studies have been inconsistent and no clear picture has emerged yet. Furthermore, no previous studies have investigated trial-by-trial learning.

Objectives

We aimed to investigate the neural underpinnings of impaired verbal learning in cannabis users as estimated over repeated learning trials.

Methods

We studied 21 adolescent-onset regular cannabis users and 21 non-users using fMRI performed at least 12 h af

SUBMITTER: Blest-Hopley G 

PROVIDER: S-EPMC8062355 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature