Expression and enhancement of FABP4 in septoclasts of the growth plate in FABP5-deficient mouse tibiae.

ABSTRACT: In our previous study, fatty acid-binding protein 5 (FABP5) was expressed in septoclasts with long processes which are considered to resorb uncalcified matrix of the growth plate (GP) cartilage, and no apparent abnormalities were detected in the histo-architecture of the GP of FABP5-deficient (FABP5^-/-) mice. Those finding lead us to hypothesize that another FABP can compensate the deletion of FABP5 in septoclasts of its gene-mutant mice. Based on the hypothesis, the present study examined the expression levels of several other FABPs in septoclasts and their morphology in FABP5^-/- mouse tibiae. Processes of FABP5^-/- septoclasts tend to be shorter than wild septoclasts. FABP4-positive septoclasts in FABP5^-/- mice were more numerous than those cell

SUBMITTER: Bando Y 

PROVIDER: S-EPMC8062382 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature