Dietary obesity in mice is associated with lipid deposition and metabolic shifts in the lungs sharing features with the liver.

ABSTRACT: Obesity is associated with both chronic and acute respiratory illnesses, such as asthma, chronic obstructive pulmonary disease (COPD) or increased susceptibility to infectious diseases. Anatomical but also systemic and local metabolic alterations are proposed contributors to the pathophysiology of lung diseases in the context of obesity. To bring perspective to this discussion, we used NMR to compare the obesity-associated metabolomic profiles of the lung with those of the liver, heart, skeletal muscles, kidneys, brain and serum from male C57Bl/6J mice fed with a high-fat and high-sucrose (HFHSD) diet vs. standard (SD) chow for 14 weeks. Our results showed that the lung was the second most affected organ after the liver, and that the two organs shared reduced one-carbon (1C) metabolism and

SUBMITTER: Rautureau GJP 

PROVIDER: S-EPMC8062462 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature