ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance.

ABSTRACT: Cyclic dinucleotide (CDN) agonists of the STimulator of InterferoN Genes (STING) pathway have shown immune activation and tumor clearance in pre-clinical models. However, CDNs administered intratumorally also promote STING activation leading to direct cytotoxicity of many cell types in the tumor microenvironment (TME), systemic inflammation due to rapid tumor extravasation of the CDN, and immune ablation in the TME. These result in a failure to establish immunological memory. ExoSTING, an engineered extracellular vesicle (EV) exogenously loaded with CDN, enhances the potency of CDN and preferentially activates antigen presenting cells in the TME. Following intratumoral injection, exoSTING was retained within the tumor, enhanced local Th1 responses and recruitment of CD8⁺ T cells

SUBMITTER: Jang SC 

PROVIDER: S-EPMC8062530 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature