Rapid uropathogen identification using surface enhanced Raman spectroscopy active filters.

ABSTRACT: Urinary tract infection is one of the most common bacterial infections leading to increased morbidity, mortality and societal costs. Current diagnostics exacerbate this problem due to an inability to provide timely pathogen identification. Surface enhanced Raman spectroscopy (SERS) has the potential to overcome these issues by providing immediate bacterial classification. To date, achieving accurate classification has required technically complicated processes to capture pathogens, which has precluded the integration of SERS into rapid diagnostics. This work demonstrates that gold-coated membrane filters capture and aggregate bacteria, separating them from urine, while also providing Raman signal enhancement. An optimal gold coating thickness of 50 nm was demonstrated, and the diagnostic p

SUBMITTER: Dryden SD 

PROVIDER: S-EPMC8062667 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature