Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens.

ABSTRACT: Neoantigen-based immunotherapy has yielded promising results in clinical trials. However, it is limited to tumor-specific mutations, and is often tailored to individual patients. Identifying suitable tumor-specific antigens is still a major challenge. Previous proteogenomics studies have identified peptides encoded by predicted non-coding sequences in human genome. To investigate whether tumors express specific peptides encoded by non-coding genes, we analyzed published proteomics data from five cancer types including 933 tumor samples and 275 matched normal samples and compared these to data from 31 different healthy human tissues. Our results reveal that many predicted non-coding genes such as DGCR9 and RHOXF1P3 encode peptides that are overexpressed in tumors compared to normal controls

SUBMITTER: Xiang R 

PROVIDER: S-EPMC8062694 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature