Comparisons of the immunological landscape between COVID-19, influenza, and respiratory syncytial virus patients by clustering analysis.

ABSTRACT:

Background

COVID-19 has stronger infectivity and a higher risk for severity than most other contagious respiratory illnesses. The mechanisms underlying this difference remain unclear.

Methods

We compared the immunological landscape between COVID-19 and two other contagious respiratory illnesses (influenza and respiratory syncytial virus (RSV)) by clustering analysis of the three diseases based on 27 immune signatures' scores.

Results

We identified three immune subtypes: Immunity-H, Immunity-M, and Immunity-L, which displayed high, medium, and low immune signatures, respectively. We found 20%, 35.5%, and 44.5% of COVID-19 cases included in Immunity-H, Immunity-M, and Immunity-L, respectively; all influenza cases were included in Immunity-H; 66.7% and 33.3% of RSV cases

SUBMITTER: Abdelrahman Z 

PROVIDER: S-EPMC8062909 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature