Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies.

ABSTRACT:

Background

The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease.

Methods

We did a pooled analysis of data from newly recruited patients with an MRI-confirmed diagnosis of lacunar stroke and existing genome-wide association studies (GWAS). Patients were recruited from hospitals in the UK as part of the UK DNA Lacunar Stroke studies 1 and 2 and from collaborators within the International Stroke Genetics Consortium. Cases and controls were stratified by ancestry and two meta-analyses were done: a European ancestry analysis, and a transethnic analysis that included all ancestry groups. We also did a multi-trait analysis of GWAS, in a jo

SUBMITTER: Traylor M 

PROVIDER: S-EPMC8062914 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature