Hamster Weight Patterns Predict the Intensity and Course of Schistosoma haematobium Infection.

ABSTRACT: Although Syrian golden hamsters are widely used as hosts for experimental infection by Schistosoma haematobium , surprisingly little is known about the course of infection and associated intensity (as defined by measures of parasite burden). As such, we sought to define inexpensive, simple, noninvasive, and accurate methods for assessing and predicting the severity of disease in S. haematobium -infected hamsters in order to prevent premature hamster sacrifice and unexpected morbidity and mortality. Through monitoring the weight and behavior of infected hamsters, we determined that the weight-loss patterns of infected hamsters are highly correlated with commonly used measures of the severity of infection (i.e., numbers of eggs passed in the stool, worm burdens, and total egg yields). In con

SUBMITTER: Le TL 

PROVIDER: S-EPMC8062915 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature