Low bicarbonate replacement fluid normalizes metabolic alkalosis during continuous veno-venous hemofiltration with regional citrate anticoagulation.

ABSTRACT:

Background

Metabolic alkalosis is a frequently occurring problem during continuous veno-venous hemofiltration (CVVH) with regional citrate anticoagulation (RCA). This study aimed to evaluate the effectiveness of switching from high to low bicarbonate (HCO₃^-) replacement fluid in alkalotic critically ill patients with acute kidney injury treated by CVVH and RCA.

Methods

A retrospective-comparative study design was applied. Patients who underwent CVVH with RCA in the ICU between 09/2016 and 11/2017 were evaluated. Data were available from the clinical routine. A switch of the replacement fluid Phoxilium^® (30 mmol/l HCO₃^-) to Biphozyl^® (22 mmol/l HCO₃^-) was performed as blood HCO₃

SUBMITTER: Koglberger P 

PROVIDER: S-EPMC8062940 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature