Association analysis of miRNA-related genetic polymorphisms in miR-143/145 and KRAS with colorectal cancer susceptibility and survival.

ABSTRACT:

Background

There is accumulating evidence of aberrant expression of miR-143 and miR-145 and their target gene KRAS in colorectal cancer (CRC). We hypothesize that single nucleotide polymorphisms (SNPs) within or near mRNA-microRNA (miRNA) binding sites may affect miRNA/target gene interaction, resulting in differential mRNA/protein expression and promoting the development and progression of CRC.

Methods

We conducted a case-control study of 507 patients with CRC recruited from a tertiary hospital and 497 population-based controls to assess the association of genetic polymorphisms in miR-143/145 and the KRAS 3' untranslated region (3'UTR) with susceptibility to CRC and patients' survival. In addition, genetic variations of genomic regions located from 500 bp upstream to 500 bp

SUBMITTER: Wang D 

PROVIDER: S-EPMC8062955 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature