Tetra-arylborate lipophilic anions as targeting groups.

ABSTRACT: Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across membranes in response to Δψ, but surprisingly, they rapidly entered cells. They accumulated within lysosomes following endocystosis. This pH-independent targeting of lysosomes makes possible new classes of probe and bioactive molecules.

SUBMITTER: Gaddale Devanna KK 

PROVIDER: S-EPMC8062962 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature