Increased sensitivity to strong perturbations in a whole-brain model of LSD.

ABSTRACT: Lysergic acid diethylamide (LSD) is a potent psychedelic drug, which has seen a revival in clinical and pharmacological research within recent years. Human neuroimaging studies have shown fundamental changes in brain-wide functional connectivity and an expansion of dynamical brain states, thus raising the question about a mechanistic explanation of the dynamics underlying these alterations. Here, we applied a novel perturbational approach based on a whole-brain computational model, which opens up the possibility to externally perturb different brain regions in silico and investigate differences in dynamical stability of different brain states, i.e. the dynamical response of a certain brain region to an external perturbation. After adjusting the whole-brain model parameters to reflect the d

SUBMITTER: Jobst BM 

PROVIDER: S-EPMC8063176 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature