A Pathophysiology of Type 2 Diabetes Unrelated to Metabolic Syndrome.

ABSTRACT:

Objective

Clinically, type 2 diabetes mellitus (T2DM) is heterogeneous, but the prevailing pathophysiologic hypothesis nevertheless contends that components of metabolic syndrome are central to all cases of T2DM. Here, we re-evaluated this hypothesis.

Research design and methods

We conducted a cross-sectional analysis of 138 women from the monocenter, post gestational diabetes study PPSDiab, 73 of which had incident prediabetes or T2DM. Additionally, we examined all the 412 incident cases of T2DM in phases 3 to 9 of the Whitehall II study in comparison to healthy controls. Our analysis included a medical history, anthropometrics, oral glucose tolerance testing, and laboratory chemistry in both studies. Additional analyses from the PPSDiab Study consisted of cardiopulmonary e

SUBMITTER: Rottenkolber M 

PROVIDER: S-EPMC8063234 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature