Changes in Ghrelin and Glucagon following a Low Glycemic Load Diet in Women with PCOS.

ABSTRACT:

Context

Altered satiety hormones in women with polycystic ovarian syndrome (PCOS) may contribute to obesity. Diets with a low glycemic load (GL) may influence appetite-regulating hormones including glucagon and ghrelin.

Objective

To test the hypothesis that following a 4-week, eucaloric low vs high GL diet habituation, a low vs high GL meal will increase glucagon and decrease ghrelin to reflect greater satiety and improve self-reported fullness.

Methods

Secondary analysis of a randomized crossover trial.

Participants

Thirty women diagnosed with PCOS.

Intervention

Participants were provided low (41:19:40% energy from carbohydrate:protein:fat) and high (55:18:27) GL diets for 8 weeks each. At each diet midpoint, a solid meal test was administered to examin

SUBMITTER: Hoover SE 

PROVIDER: S-EPMC8063255 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature