An atlas of the tissue and blood metagenome in cancer reveals novel links between bacteria, viruses and cancer.

ABSTRACT:

Background

Host tissue infections by bacteria and viruses can cause cancer. Known viral carcinogenic mechanisms are disruption of the host genome via genomic integration and expression of oncogenic viral proteins. An important bacterial carcinogenic mechanism is chronic inflammation. Massively parallel sequencing now routinely generates datasets large enough to contain detectable traces of bacterial and viral nucleic acids of taxa that colonize the examined tissue or are integrated into the host genome. However, this hidden resource has not been comprehensively studied in large patient cohorts.

Methods

In the present study, 3025 whole genome sequencing datasets and, where available, corresponding RNA-seq datasets are leveraged to gain insight into novel links between viruses

SUBMITTER: Borchmann S 

PROVIDER: S-EPMC8063312 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature