Hydropathicity-based prediction of pain-causing NaV1.7 variants.

ABSTRACT:

Background

Mutation-induced variations in the functional architecture of the NaV1.7 channel protein are causally related to a broad spectrum of human pain disorders. Predicting in silico the phenotype of NaV1.7 variant is of major clinical importance; it can aid in reducing costs of in vitro pathophysiological characterization of NaV1.7 variants, as well as, in the design of drug agents for counteracting pain-disease symptoms.

Results

In this work, we utilize spatial complexity of hydropathic effects toward predicting which NaV1.7 variants cause pain (and which are neutral) based on the location of corresponding mutation sites within the NaV1.7 structure. For that, we analyze topological and scaling hydropathic characteristics of the atomic environment around NaV1.7's pore a

SUBMITTER: Xenakis MN 

PROVIDER: S-EPMC8063372 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature