Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study.

ABSTRACT:

Background

Whether a modestly elevated homocysteine level is causally associated with an increased risk of cardiovascular disease remains unestablished. We conducted a Mendelian randomization study to assess the associations of circulating total homocysteine (tHcy) and B vitamin levels with cardiovascular diseases in the general population.

Methods

Independent single nucleotide polymorphisms associated with tHcy (n = 14), folate (n = 2), vitamin B6 (n = 1), and vitamin B12 (n = 14) at the genome-wide significance level were selected as instrumental variables. Summary-level data for 12 cardiovascular endpoints were obtained from genetic consortia, the UK Biobank study, and the FinnGen consortium.

Results

Higher genetically predicted circulating tHcy levels were associa

SUBMITTER: Yuan S 

PROVIDER: S-EPMC8063383 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature