Divergent airway microbiomes in lung transplant recipients with or without pulmonary infection.

ABSTRACT:

Background

Lung transplant (LTx) recipients are at increased risk for airway infections, but the cause of infection is often difficult to establish with traditional culture-based techniques. The objectives of the study was to compare the airway microbiome in LTx patients with and without ongoing airway infection and identify differences in their microbiome composition.

Methods

LTx recipients were prospectively followed with bronchoalveolar lavage (BAL) during the first year after transplantation. The likelihood of airway infection at the time of sampling was graded based on clinical criteria and BAL cultures, and BAL fluid levels of the inflammatory markers heparin-binding protein (HBP), IL-1β and IL-8 were determined with ELISA. The bacterial microbiome of the samples were

SUBMITTER: Pahlman LI 

PROVIDER: S-EPMC8063417 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature