PKU and COVID19: How the pandemic changed metabolic control.

ABSTRACT:

Background

COVID19 pandemic urged the need to take severe measures for reducing the epidemic spread. Lockdowns were imposed throughout countries and even Inborn errors of metabolism (IEMs) affected patients had to face it and adapt, with management strategies changes coming along. Phenylketonuria (PKU) is an inborn error of phenylalanine (Phe) metabolism causing, when not treated, blood Phe increases and consequent central nervous system (CNS) damage. Dietary intervention is the main recognized treatment and must be maintained long-life, however adherence is often suboptimal in adulthood. Aim of this study was to evaluate whether and how the pandemic had impacted PKUs metabolic control and what factors may have played a role as potential modifiers.

Methods

Patients ≥4 yo and

SUBMITTER: Rovelli V 

PROVIDER: S-EPMC8063433 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature