Genome-wide association and transcriptome studies identify candidate genes and pathways for feed conversion ratio in pigs.

ABSTRACT:

Background

The feed conversion ratio (FCR) is an important productive trait that greatly affects profits in the pig industry. Elucidating the genetic mechanisms underpinning FCR may promote more efficient improvement of FCR through artificial selection. In this study, we integrated a genome-wide association study (GWAS) with transcriptome analyses of different tissues in Yorkshire pigs (YY) with the aim of identifying key genes and signalling pathways associated with FCR.

Results

A total of 61 significant single nucleotide polymorphisms (SNPs) were detected by GWAS in YY. All of these SNPs were located on porcine chromosome (SSC) 5, and the covered region was considered a quantitative trait locus (QTL) region for FCR. Some genes distributed around these significant SNPs were

SUBMITTER: Miao Y 

PROVIDER: S-EPMC8063444 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature