Quercetin prevents primordial follicle loss via suppression of PI3K/Akt/Foxo3a pathway activation in cyclophosphamide-treated mice.

ABSTRACT:

Background

Chemotherapy improves the survival rates of patients with various cancers but often causes some adverse effects, including ovarian damage, characterised by a decrease in primordial follicle stockpiles. Recent studies have revealed that chemotherapy may stimulate the PI3K signalling pathway, thereby resulting in accelerated primordial follicle activation and a decreased ovarian reserve. Quercetin is an inhibitor of the PI3K pathway; however, its protective effects against chemotherapy-induced follicle loss in mice have not been established. In this study, the effects of quercetin in a mouse model of cyclophosphamide-induced ovarian dysfunction were investigated.

Methods

C57BL/6 female mice were used for the study. Paraffin sections of mouse ovaries (n = 30 mice) we

SUBMITTER: Li J 

PROVIDER: S-EPMC8063466 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature